Engineering enzymes to locally suppress inflammation

Chronic inflammation underlies onset and progression of numerous diseases affecting the lives of millions of people each year. Our enzyme technology resolves inflammation only at the site of disease by mimicking a natural mechanism of localized immunosuppression.  

IDO is an enzyme that naturally regulates the immune system. Our invention resets the immune system to promote healthy tissue function by installing IDO at sites of inflammation. Restricting distribution avoids off-target side-effects.

Conventional enzyme therapeutics rapidly diffuse away from where they are needed. Our technology anchors IDO to the injection site. Specifically, we fuse IDO to galectin-3, a protein that binds to sugars decorating all tissues in the human body.